Scientist i - (Framingham, MA)

Job summary: The Scientist I/II will report to the Neurology Program Lead and will work as part of a multidisciplinary team on drug development efforts to modulate activities of targets identified by Berg Interrogative Biology(R) Platform and on evaluating efficacy of novel drug applicants for Parkinson's and other neurodegenerative diseases. Responsibilities: *Develop cell-based and biochemistry assays for phenotypic screens (low to medium throughput) and potency assays to validate novel drug applicants. *Design and execute in vitro studies to demonstrate compound pharmacodynamics and support development of early drug applicants and lead molecules. *Generate and utilize molecular biology reagents (including CRISPR gene-editing tools) for mechanism of action studies and to develop screening models. *Critically analyze data and communicate findings effectively to multidisciplinary teammates and management.